you take any statin medications it is essential to supplement with CoQ10 to limit that side effect. The usual recommended dose is 100–300 mg daily, but you should double this if you are on a statin. Note that it may decrease the effectiveness of blood-thinning medications such as warfarin (Coumadin) or clopidogrel (Plavix), so they should be taken together only under the careful supervision of your health care provider.