is this overactive immune response, not a viral infection, that leads to fatigue, low-grade fevers, sore throat, and swollen lymph nodes. Fibromyalgia, on the other hand, usually has a gradual onset, and is not associated with fevers, sore throats, or lymph node swelling. For patients with both fibromyalgia and chronic fatigue syndrome, I find that they still need my complete four R’s regimen, but also benefit from addressing any immune system problems directly.