pharmaceutical estrogen therapy does not focus the drug’s effects on the intended target tissues. The drug also impacts and disturbs the estrogen receptors of the heart, the blood vessels, and the nervous system. Synthetic hormone replacement therapy has been shown to have disturbing side effects that result in cardiovascular disease and neural dysfunctions such as strokes. (Shumaker, et al, 2003; Wassertheil-Smoller, et al, 2003; Anderson, et al, 2003; Cauley, et al, 2003; Bath and Gray 2005)
