Too little cortisol can wreak its own havoc. Cortisol plays a key role in converting the thyroid storage hormone T4 into the usable hormone T3, and in allowing the T3 to penetrate and “charge up” your cells. When your adrenals underperform, they can create a thyroid hormone shortage on the cellular level. In this case, even if you have a healthy thyroid that’s testing as normal, you can experience hypothyroid symptoms such as weight gain, depression, hair loss, brittle nails, rough or thinning skin, feeling cold, fluctuating blood sugar, and a myriad of other issues.