In the 1980s, Vogelstein and his colleagues effectively proved how DNA mutations turn into cancer. Since then, as a result of his work, more than 150 genes have been identified as key actors behind the development and spread of cancer. After proving the relationship between damaged DNA and cancer, Vogelstein began an intensive period of investigation into the meaning of this correlation, trying to figure out how to detect cancers earlier and earlier in their development so that they can be treated before becoming incurable.
