In contrast, when you have a challenge response, the brain is more likely to learn resilience from a stressful experience. In part, this is because you release more resilience-boosting hormones, including DHEA and nerve growth factor. The rewiring that takes place in your brain following a challenge response strengthens the connections between the parts of the brain’s prefrontal cortex that suppress fear and enhance positive motivation during stress. In this way, a challenge response makes it more likely that you will experience stress inoculation as a result of your experience.