The Vital Question: Why is life the way it is?

by Nick Lane

I hope to persuade you that energy is central to evolution, that we can only understand the properties of life if we bring energy into the equation. I want to show you that this relationship between energy and life goes right back to the beginning – that the fundamental properties of life necessarily emerged from the disequilibrium of a restless planet. I want to show you that the origin of life was driven by energy flux, that proton gradients were central to the emergence of cells, and that their use constrained the structure of both bacteria and archaea. I want to demonstrate that these constraints dominated the later evolution of cells, keeping the bacteria and archaea forever simple in morphology, despite their biochemical virtuosity. I want to prove that a rare event, an endosymbiosis in which one bacterium got inside an archaeon, broke those constraints, enabling the evolution of vastly more complex cells. I want to show you that this was not easy – that the intimate relationship between cells living one inside another explains why morphologically complex organisms only arose once. I hope to do more, to persuade you that this intimate relationship actually predicts some of the properties of complex cells. These traits include the nucleus, sex, two sexes, and even the distinction between the immortal germline and the mortal body – the origins of a finite lifespan and genetically predetermined death. Finally, I want to convince you that thinking in these energetic term...