First, arteries are naturally impervious to the entry of cholesterol. Second, human arterial disease is highly selective; it occurs typically only in short sections of the (damaged) arteries and never affects veins, which constitute a major portion of the vessels in the human circulation. This shows that something other than simply the blood cholesterol concentration determines whether human blood vessels will or will not be damaged by cholesterol. Third, the majority of persons who develop heart disease in countries like the US have blood LDL-cholesterol levels below the cut-off value
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