Caffeine affects even insect predators dramatically. In the late 1990s, scientists at NASA illustrated the effects of various drugs on the web-spinning abilities of spiders. The eight-legged creature fared disastrously under the influence of caffeine. It strung a few threads in a chaotic, random pattern that bore little resemblance to a web it would have spun under normal circumstances. Generally, insects leave the plant alone, except coffee borer beetles which have developed immunity.