The Upward Spiral: Using Neuroscience to Reverse the Course of Depression, One Small Change at a Time

by Alex Korb

Importantly, serotonin and BDNF are particularly good at creating an upward spiral, because serotonin stimulates the production of BDNF, and BDNF strengthens serotonin neurons.14 Exercise sets the snowball in motion, and the brain’s dynamic interactions keep it going.