Interestingly, the neurotransmitter serotonin is highly concentrated in the anterior cingulate. That’s important for depression, because serotonin is the neurotransmitter system most commonly targeted by antidepressant medications. In fact, activity in anterior cingulate can predict who will get better on antidepressant medication and who won’t (shout-out to my dissertation).8 In addition, directly stimulating the anterior cingulate with electrodes can vastly improve depressive symptoms.
