Pretty much the whole prefrontal cortex is affected by depression.3 Not feeling any motivation? It’s likely the fault of reduced serotonin in the ventromedial prefrontal cortex. Finding it difficult to make plans or think clearly? It’s probably disrupted activity in your dorsolateral prefrontal cortex. However, most problems, like difficulty in following through with plans, cannot always be pinpointed to one region or neurotransmitter system and often result from the communication between several of them.
