Depressed mood, such as feeling sad or empty or even constantly irritable Decreased interest or pleasure in all—or almost all—activities Significant (and unintentional) weight loss, weight gain, or decrease or increase in appetite Insomnia or increased desire to sleep Either restlessness or slowed behavior that can be observed by others Fatigue or loss of energy Feelings of worthlessness, or excessive or inappropriate guilt Trouble thinking, concentrating, or making decisions Recurrent thoughts of death or suicide1
