DuPont is a tall, thin, genial man from Ohio, and he delivered the knockout speech of the conference—an eloquent rallying call for the drug war, summing up a conference that warned that chemicals can hijack your brain and cause chemical slavery. He agreed to let me put to him some of the possible holes in the theory, and as we spoke, he listened intently. I started by asking how many of the negative effects of drugs he believed are driven by their pharmacological component. He looked at me blankly. “As opposed to . . . ?” And there was a silence.

