In general, releasing agents are fraught with danger because they tend to rob future neurotransmitters to feed the present. For example, reuptake inhibitors gradually increase serotonin over time, whereas releasing agents dump everything into the synapse, leaving none for tomorrow. This means, as a general rule regarding depression and anxiety, releasing agents make you feel much better today and then much worse tomorrow as your brain just can’t replenish levels of neurotransmitters quickly enough to keep up.
