D. When You Feel Defeated, THINK BIG. It is not possible to achieve large success without hardships and setbacks. But it is possible to live the rest of your life without defeat. Big thinkers react to setbacks this way: 1. Regard the setback as a lesson. Learn from it. Research it. Use it to propel you forward. Salvage something from every setback. 2. Blend persistence with experimentation. Back off and start afresh with a new approach. Think Big Enough to see that defeat is a state of mind, nothing more.