Super Agers: An Evidence-Based Approach to Longevity

by Eric Topol

The problem with a strict calorie-restricted diet is that it is hard to adhere to, has been associated with loss of bone density and muscle mass, and slowed brain function. Our brain is only 2 percent of our body mass but consumes 20 percent of our calorie intake. On the other hand, multiple studies support an improved immune response, and, perhaps interrelated, potential antitumor effects show up in experimental models. No calorie-restricted, time-restricted, or intermittent fasting diets have been proven to provide antiaging properties, but a small, randomized trial showed reduction of a biological age score that relied on some improvements of biomarkers (immune system, liver, glucose regulation) with multiple cycles of a fasting-mimicking diet. Until there’s more definitive evidence, perhaps the best practical advice is to eat an early dinner, at least three to four hours before going to bed, and avoid any caloric intake before the next morning’s breakfast.