The large island of Madagascar, about 250 miles east of the African mainland, offers a famous example. Through millions of years of isolation, a unique collection of animals evolved there. These included the elephant bird, a flightless creature ten feet tall and weighing almost half a ton – the largest bird in the world – and the giant lemurs, the globe’s largest primates. The elephant birds and the giant lemurs, along with most of the other large animals of Madagascar, suddenly vanished about 1,500 years ago – precisely when the first humans set foot on the island.