Ever since Europeans had laid eyes on Native Americans in 1492, a people unmentioned in the Bible, they had started questioning the biblical creation story. Some speculated that Native Americans had to have descended from “a different Adam.” By the end of the sixteenth century, European thinkers had added African people to the list of species descended from a different Adam. In 1616, Italian freethinker Lucilio Vanini said—as Locke suggested later—that Ethiopians and apes must have the same ancestry, distinct from Europeans.