Cannon had discovered the “fight-or-flight response” and this rewrote the rule book. Until then, performance enhancement had always been divine in origin. Want to write a sonnet? Talk to the Muses. Want a better time in the 100-yard dash? Hermes can help. But the fight-or-flight response changed the equation, turning a gift from the gods into a byproduct of standard biology. And biology was hackable.