Tribes in Mississippi, Alabama, and Florida are stripped of lands they have owned for generations and are forcibly relocated west of the Mississippi. By the end of his two terms, Jackson will remove almost all tribes east of that river—seventy thousand individuals. The brutal relocation will become known as the Trail of Tears due to the thousands of men, women, and children who die from disease, unsanitary conditions, and exposure to the elements while making the long march to the Oklahoma Territory.