Dan Seitz

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In Europe, Asia, and Africa smallpox became a constant, terrible presence, infecting almost every child, killing many and leaving others with the disfiguring pockmarks that are its telltale sign. Survivors become immune to the disease. Because most Europeans contracted the disease in childhood, the great majority of European adults, the conquistadors among them, were immune.
1491: New Revelations of the Americas Before Columbus
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