Smallpox not only killed Wayna Qhapaq, it killed his son and designated heir—and his brother, uncle, and sister-wife. The main generals and much of the officer corps died, wrote the Inka chronicler Santacruz Pachacuti Yamqui Salcamayhua, “all their faces covered with scabs.” So did the two regents left in Qosqo by Wayna Qhapaq to administer the empire.

