HSP90 ‘insists’ that proteins fold into the orthodox shape, even if there are a few mutations in the DNA that codes for those proteins. When the organism is ‘stressed’, diverting HSP90 to other functions, these cryptic mutations suddenly get expressed – the proteins acquire the unorthodox shape that goes along with their mutated DNA codes. In effect, this says that you can trigger a genetic change by non-genetic means.
Dang
