I’m going to argue that there is: the fact that our Universe appears highly fine-tuned for life. Basically, we’ve discovered that many of those knobs that we discussed appear tuned to very special values, and if we could change them even by quite small amounts, then life as we know it would become impossible. Tweak the dark-energy knob and galaxies never form, tweak another knob and atoms become unstable, and so on.
