Dr. Ladapo wrote, “DNA integration could theoretically impact a human’s oncogenes—the genes which can transform a healthy cell into a cancerous cell. DNA integration may result in chromosomal instability. The Guidance for Industry discusses biodistribution of DNA vaccines and how such integration could affect unintended parts of the body including blood, heart, brain, liver, kidney, bone marrow, ovaries/testes, lung, draining lymph nodes, spleen, the site of administration and subcutis at injection site.”