Gluten is the component of wheat confidently linked with triggering destructive immune phenomena, whether expressed as celiac disease, cerebellar ataxia, or dementia. However, many health effects of wheat, including those on the brain and nervous system, have nothing to do with immune phenomena triggered by gluten. The addictive properties of wheat, for instance, expressed as overwhelming temptation and obsession, obstructed by opiate-blocking drugs, are not directly due to gluten, but to exorphins, the breakdown product of gluten.