We therefore have good evidence that the apparent increase in celiac disease (or at least the immune markers to gluten) is not just due to better testing: The disease itself has increased in frequency, fourfold over the past fifty years, doubling in just the past twenty years. To make matters worse, the increase in celiac disease has been paralleled by an increase in type 1 diabetes, autoimmune diseases such as multiple sclerosis and Crohn’s disease, and allergies.