God's hand is in every trouble which breaks into the lives of men. Not that He directly and arbitrarily orders every unpleasant experience of life. Not that He is personally responsible for every painful and afflicting thing which comes into the lives of His people. But no trouble is ever turned loose in this world and comes into the life of saint or sinner, but comes with Divine permission, and is allowed to exist and do its painful work with God's hand in it or on it, carrying out His gracious designs of redemption.
