One of the factors that drive the climate changes over periods of millions of years is the changing geography of the Earth. 50 million years ago there was no Mediterranean Sea. There was a vast ocean from the continent of India to the continental shelf north of the African continent. The portion of the Earth that is now Spain to the Himalayas, were a series of tropical islands surrounded by warm oceans. All of that land has now merged together and the warm oceans and seas that separated them are gone. Only the small Mediterranean remains. Oceans do not have big temperature changes, land does.
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