In this book we have presented evidence that weight is normally tightly regulated and stable. To change to a higher weight, animals must stimulate oxidative stress in their mitochondria, or energy factories, in which the energy that is ingested from food is preferentially shunted to fat as opposed to ATP. The low ATP state causes fatigue and further stimulates food intake. Leptin resistance also develops, leading to more food intake that helps to recover the ATP levels at the expense of increasing fat stores. The relative shunting of energy to fat leads to an accumulation of fat in the liver,
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