I even came to realize that many guys pitch differently with a base runner on second than they do with a base runner on third. In both cases, the runner is in scoring position. However, with a runner on second, pitchers don’t have to worry so much about the hitter making contact, so to keep hitters off balance, pitchers tend to throw curveballs and sliders in the strike zone; with a runner on third and the prospect of simple contact resulting in a run, pitchers tend to throw more fastballs high and inside, as that’s a pitch often popped up or fouled back. Also, many pitchers throw fewer
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