endorphins do for us exactly what plant-derived opioids can do: they’re powerful soothers of pain, both physical and emotional. They grant, in the words of that opiate disciple Thomas De Quincey, “serenity, equipoise … the removal of any deep-seated irritation.” For the distracted and soul-suffering person, a hit of endorphins, just like an infusion of opium products, “composes what has been agitated, concentrates what has been distracted.”