William Styron renders an eloquent description of “the many dreadful manifestations of the disease,” among them self-hatred, a sense of worthlessness, a “dank joylessness” with “gloom crowding in on me, a sense of dread and alienation and, above all, a stifling anxiety.”14 Then there are the intellectual marks: “confusion, failure of mental focus and lapse of memories,” and, at a later stage, his mind “dominated by anarchic distortions,” and “a sense that my thought processes were engulfed by a toxic and unnameable tide that obliterated any enjoyable response to the living world.” There are
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