One of the most potent—and, outside therapy, little used—antidotes to depression is seeing things differently, or cognitive reframing. It is natural to bemoan the end of a relationship and to wallow in self-pitying thoughts such as the conviction that “this means I’ll always be alone,” but it’s sure to thicken the sense of despair. However, stepping back and thinking about the ways the relationship wasn’t so great, and ways you and your partner were mismatched—in other words, seeing the loss differently, in a more positive light—is an antidote to the sadness.