The low mutability of wild genes was distinctly increased, but the comparatively high mutability occurring with some of the already mutated genes was not, or at any rate was much less, increased. That is just what we expect on comparing our two formulae. A large value of W/kT, which according to the first formula is required to make t large (stable gene), will, according to the second one, make for a small value of the ratio computed there, that is to say for a considerable increase of mutability with temperature.