Many evolutionary biologists have simply regarded mathematical challenges to the creative power of the mechanism, coming as they mostly do from scientists and engineers in other fields, as exotic or irrelevant. That has begun to change. And it has begun to change in a way that has not only introduced a new mathematical challenge to the creative power of the neo-Darwinian mechanism, but also in a way that indirectly confirms Axe’s key insight about the rarity of genes and proteins.

