Based on the physical principles of protein function, the vast majority of protein functions simply cannot be performed by unfolded proteins. In other words, stability of protein structure is a precondition of protein function. Destabilized protein folds not only lose the three-dimensional structures they need to perform functional tasks, they are also vulnerable to attack by other proteins called proteases that devour unfolded proteins or polypeptides in the cell.12 As one structure is degraded as the result of multiple sequence changes, it will necessarily lose structural stability,
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