The nation’s inattentiveness notwithstanding, the Mississippi flood of 1927 was the most epic natural disaster in American history in extent, duration, and number of lives affected. The scale of economic loss was so large as to be essentially incalculable. Estimates ranged from $250 million to $1 billion. It wasn’t the most lethal catastrophe in American history, but it ruined more livelihoods and property than any other, and it lasted far longer.