John

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My guess is that he was a manic-depressive. The disorder ran in his family. If this is true, then it was his special triumph that he seldom let his emotional state take over, and then only momentarily. Whether he was high or low, his emotional state played no role in daily decision-making for two and a half years.
Undaunted Courage: Meriwether Lewis, Thomas Jefferson, and the Opening of the American West
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