How do we keep certain genes turned on and others turned off? If we stay in the same toxic state of anger, the same melancholy state of depression, the same vigilant state of anxiety, or the same low state of unworthiness, those redundant chemical signals we have talked about keep pushing the same genetic buttons, which ultimately cause the activation of certain diseases. Stressful emotions, as you will learn, actually pull the genetic trigger, dysregulating the cells (dysregulation refers to impairment of a physiological regulatory mechanism) and creating disease.