As a result of normal daily changes in brain chemistry (alternately, the brain produces serotonin, primarily a daytime neurotransmitter that makes you alert; and melatonin, the nighttime neurotransmitter that begins to relax you for sleep), there are two times when the door to the subconscious mind opens—when you go to bed at night and when you wake up in the morning. So it is a good idea to meditate in the morning or evening, because it will be easier to slip into a state of Alpha or Theta.