Bigger Leaner Stronger: The Simple Science of Building the Ultimate Male Body

by Michael Matthews

Synephrine is a chemical compound found in certain types of citrus fruits (particularly the bitter variety). It’s chemically similar to ephedrine and catecholamines, and although less potent, it induces similar effects in the body. Research shows that supplementation with synephrine increases both basal metabolic rate and lipolysis, inhibits the activity of certain types of fat cell receptors that prevent fat mobilization, and increases the thermic effect of food (which, in case you don’t remember, is the “energy cost” of metabolizing food).75 Furthermore, research shows that synephrine works synergistically with caffeine to enhance both caffeine’s and its own fat-loss properties.76 The synergism noted in a standard “ECA” (ephedrine, caffeine, and aspirin) stack also applies to synephrine.