Glutamine is the most abundant amino acid in the body and is heavily depleted by intense, prolonged exercise.57 Research has shown that supplementation with glutamine can… • reduce the negative effects of prolonged exercise on the immune system (research has shown that exercise depletes glutamine levels in the body, which in turn can impair immune function), • improve your endurance and reduce fatigue in prolonged exercise, and • help your body better deal with the systemic stress of prolonged exercise.58