“How weary, stale, flat and unprofitable, seem to me all the uses of this world,” said Hamlet,[18] immediately after lamenting God’s prohibition against “self-slaughter.” For a diagnosis of MDD, these symptoms must be consistently present for at least two weeks. They are often accompanied by physical symptoms, including significant weight loss or weight gain, sleeping far less or far more than normal, and fatigue. They are also accompanied by disordered thinking, including an inability to concentrate, dwelling on one’s transgressions or failings (causing feelings of guilt) and the many
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