Nonetheless, reexaminations of the fewer younger women (those fifty to fifty-nine) included in the WHI provided important evidence that HRT started in midlife may indeed help to reduce the risk of dementia. Results show that, as these women got older, those taking estrogen in midlife didn’t develop cognitive declines nearly as often as those given a placebo. Several observational studies report similar findings, prompting many clinicians to advocate for taking HRT during perimenopause or early menopause to sustain neurological health in older age.
