Today NIH, along with the NSF, are irreplaceable. If these institutions had never been created or expanded, the lives of millions, even billions of people around the world would be shorter than they are today, and people would be sicker. If they disappeared tomorrow, the world would instantly be worse.63 But it is precisely because the NIH stands above every bioscience institution in significance that we should scrutinize the way it shapes the practice of science in America and around the world.