Man’s search for meaning is the primary motivation in his life and not a “secondary rationalization” of instinctual drives.
If man's search for meaning WERE indeed a product of his instinctual drives, there would be no possible way for him to realize that fact, since any rationalization is inevitably subject to those instinctual drives. In fact, it would probably be an evolutionary advantage for humans to believe that their search for meaning transcends everything else – those who do are more motivated and therefore more likely to survive than those who don't.
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