This put it out of question to me, that the calamity was spread by infection; that is to say, by some certain steams or fumes, which the physicians call effluvia, by the breath, or by the sweat, or by the stench of the sores of the sick persons, or some other way, perhaps, beyond even the reach of the physicians themselves, which effluvia affected the sound who came within certain distances of the sick, immediately penetrating the vital parts of the said sound persons, putting their blood into an immediate ferment, and agitating their spirits to that degree which it was found they were
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Defoe's theory on how the Plague was spread
