Spermidine is particularly interesting. Adding it to the diets of laboratory animal models extended their life spans by 15 to 30 percent. In human cells bathed in spermidine, aging also slowed. However, we are only just beginning to understand the potential mechanisms. One effect of spermidine is that it helps keep our genes switched off. As cells age, more and more genes get turned on willy-nilly. The firing of too many genes can be problematic. Spermidine seems to keep older cells operating as they did when they were younger by reversing this trend to some degree. Small clinical trials show
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